Diacylglycerol kinases (DGKs) terminate signalling from diacylglycerol by converting it to phosphatidic acid. Diacylglycerol regulates cell growth and differentiation, and its transient accumulation in the nucleus may be particularly important in this regulation,. Here we show that a fraction of DGK-ζ is found inthe nucleus, where it regulates the amount of nuclear diacylglycerol. Reducing

överätande har valts: PFC, ST, nucleus accumbens (NAc) och HCP. 2013), and DGK ζ (regulation of the endocannabinoid activity: Liu et al,

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TCR stimulation, however, promotes anergy. One DGK, DGK-zeta, contains both a nuclear localization signal and nuclear export signal , suggesting a shuttling between the nucleus and the cytoplasm. Morphological studies on animal tissues report that DGK-zeta predominantly localizes to the nucleus in some cell types, while it exhibits both nuclear and cytoplasmic localization in others. 1998-08-13 2001-06-29 The nucleus contains diacylglycerol kinases (DGKs), i.e., the enzymes that, by converting diacylglycerol (DG) into phosphatidic acid, terminate DG‐dependent events.It has been demonstrated that nuclear DGK‐ζ interferes with cell cycle progression. We previously reported that nuclear DGK‐ζ expression increased during myogenic differentiation, whereas its down‐regulation impaired 2013-04-17 Our investigations of DGK in IIC9 nuclei revealed the presence of two isoforms: DGK θ, which is regulated upon stimulation with the growth factor α-thrombin, and DGK δ, which is constitutively active during the investigated time course.

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We previously reported that nuclear DGK‐ζ expression increased during myogenic differentiation, whereas its down‐regulation impaired 2013-04-17 Our investigations of DGK in IIC9 nuclei revealed the presence of two isoforms: DGK θ, which is regulated upon stimulation with the growth factor α-thrombin, and DGK δ, which is constitutively active during the investigated time course. 2001-04-17 Heterologous expression demonstrates that DGK is expressed in the nucleus and cytoplasm. A, COS-7 cells transfected with human DGK in an expression vector express a 130-kDa protein. The nucleus contains diacylglycerol kinases (DGKs), i.e., the enzymes that, by converting diacylglycerol (DG) into phosphatidic acid, terminate DG‐dependent events.It has been demonstrated that nuclear DGK‐ζ interferes with cell cycle progression. We previously reported that nuclear DGK‐ζ expression increased during myogenic differentiation, whereas its down‐regulation impaired DGK-ζ also displays a functional independent nuclear export signal (NES) sequence between the amino acid residues 362-370. Mutation of DGK-ζ NES was performed by replacing leucines with alanines using site-directed mutagenesis. The NES mutant forms of DGK-ζ accumulated in the nucleus of C2C12 myoblasts to a much greater ex- Of DGK isozymes, DGKζ localizes to the nucleus in various cells such as neurons.

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2020-10-10 · DGK-zeta export from nucleus to cytoplasm is regulated by a leucine-rich nuclear export signals through the exportin 1. In DGKzeta-deficient fibroblasts PAK1 phosphorylation and Rac1-RhoGDI dissociation were attenuated, leading to reduced Rac1 activation after platelet-derived growth factor stimulation.

in Form von verschiedenen Projekten Ihrer Nukleusmitglieder an grundlagenwissenschaftlichen, translationalen und klinischen Forschungsprojekten auf dem Gebiet der Atmungsstörungen und Somnologie teil. a, Immunoblot (for DGK-ζ) of total cellular homogenates or nuclear fractions (10 µg protein per lane) from COS-7 cells into which DGK-ζ had been transfected with control vector or with PKC-α It closely resembles the eye-specific DGK of Drosophila that is encoded by rdgA (Masai et al., 1993) in that DGKζ contains ankyrin-like repeats, but no EF-hand motifs. Characteristically, an NLS is included in mammalian DGKζ (Goto and Kondo, 1996), but is not present in the corresponding region of Drosophila DGK (rdgA). The NLS is a bipartite Diacylglycerol kinases (DGKs) terminate signalling from diacylglycerol by converting it to phosphatidic acid.

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and a soft gelatinous core, called "Nucleus Pulposus" (Figure 1). In breeds without chondrodystrophic dwarfism, the nucleus contains some molecules that are capable of attracting water. They maintain a fine balance that ensures that the gel-like mass remains soft and elastic. However, in the short-legged breeds, the molecular composition of the

Nukleus (gewählt am 11.10.2018) Prof. Dr. Udo Boeken, Düsseldorf. Prof.